Background: Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death\namong peopleââ?¬â?¢s living human immunodeficiency virus. Though manifold factors have reported as determinant factors\nof antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of\npatients in the study setting.\nMethods: An institution based unmatched caseââ?¬â??control study was conducted in Aksum town. Individuals who\nhad a 6-month follow-up with complete individual information were included in the study. Document review and\ninterviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the\ndeterminant factors of non-adherence.\nResults: A total of 411 (137 cases and 274 control) study participants were included in the study. The majority of\nthem were male in sex. Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse\neffect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95%\nCI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm3 cluster of differentiation 4\ncount [AOR = 3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR = 2, 95% CI (1.1, 3.7)] were found significant determinants\nof non-adherence to antiretroviral drug.\nConclusion: Program, social and individual related factors showed a statistically significant associated with nonadherence\nto antiretroviral therapy. Managing lifestyle by developing self-efficacy of individuals and treating related\nthreat to improve adherence status of antiretroviral therapy is recommended in this study.
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